Summary of the 2025 Research Roundtable

The CACNA1A Foundation hosted its 4th Annual CACNA1A Research Roundtable on Monday, November 3rd. For the first time, the meeting was held virtually—an adjustment that enabled our largest research gathering to date. The global CACNA1A Research Network brought together 70 researchers, clinicians, industry representatives, and consultants to discuss how to continue advancing research toward clinical trials. The meeting built on recent progress in therapeutic development for CACNA1A-related disorders—advances made possible in part through Foundation-funded projects. Given the wide spectrum of disorders and range of severity, our research strategy remains focused on pursuing “multiple shots on goal” to achieve the greatest possible impact for the entire CACNA1A community.

The roundtable featured two sessions, five presentations on the latest CACNA1A research, and productive discussions centered on:

• Outlining the pathway for biomarker discovery and identifying endpoints and outcome measures based on CACNA1A patient data.

• Defining the critical next steps for moving potential therapeutic approaches from academic research into clinical trials.

We are grateful to all who attended and continue to work with us on the path toward clinical trials. A detailed summary will be shared in the January newsletter.